PLP-dependent H2S biogenesis

PLP-Dependent Enzymes

The main focus of this special issue is on structural, functional, and biomedical studies on pyridoxal-5-phosphate(PLP-) dependent enzymes. The unparalleled catalytic versatility of PLP, the active form of vitamin B6, originates from its unique electron-sinking properties, which stabilize reaction intermediates, thus lowering the activation barrier during catalysis. At least five different prot...

The PLP System

Beat Detection Using Plp

We report here about our submission to both the Beat Tracking and the Tempo Estimation tasks for the MIREX 2010 evaluations. Our submission consists of an adaptation of the technique presented at ISMIR 2009 by Peter Grosche and Meinard Müller [1]. Assuming that most of the music the system is going to deal with will belong to pop-rock genres, we further add some post-processing techniques in wh...

Nitrite Reductase Activity and Inhibition of H2S Biogenesis by Human Cystathionine ß-Synthase

Nitrite was recognized as a potent vasodilator >130 years and has more recently emerged as an endogenous signaling molecule and modulator of gene expression. Understanding the molecular mechanisms that regulate nitrite metabolism is essential for its use as a potential diagnostic marker as well as therapeutic agent for cardiovascular diseases. In this study, we have identified human cystathioni...

Novel Flp pilus biogenesis-dependent natural transformation

Natural transformation has been described in bacterial species spread through nearly all major taxonomic groups. However, the current understanding of the structural components and the regulation of competence development is derived from only a few model organisms. Although natural transformation was discovered in members of the Actinobacteria (high GC Gram-positive bacteria) more than four dec...